a case of unresectable unicentric Castleman’s disease that indicated significant response after radiotherapy *
Castleman's disease is a rare, benign lymphoproliferative disorder of unknown origin. The mediastinum is most commonly affected by this disease, followed by the cervical lymph nodes. An 70－year-old woman was referred to our hospital for examination and treatment of an intraabdomial mass. Physical examination disclosed a fist-sized, relatively well-defined painless mass in the lower abdomen. Ultrasonograghy and Computed tomography（CT）revealed sandwich sign which penetrated a stem of the upper mesentery artery and the bifurcation. The serum levels of SIL-2R and TK increased sightly（618 IU/ml and 6.1Ul/l, respectively）, and that of amyloid A increased significantly（517 mg/ml）. A biopsy specimen obtained by laparosupic surgery displayed the features of Castleman's disease（hyaline vascular type）. Radiotherapy was performed because thus unicentric Castleman's disease was unresectable. A remarkable response was obtained.（Accepted on August 30，2006）
