A basic study of super-selective transcatheter arterial chemotherapy and chemoembolization (1) -Establishment of an animal model for super-selective transcatheter arterial chemotherapy and preparation for appropriate suspension of microembolization – *
Purposes : It is well known that super-selcctivc transcatheter arterial chemotherapy produces good results in the treatment of malignant tumors and has a greater potential lumoricidal effect in clinical practice when microcmbolization is included with the arterial chemotherapy. But the mechanisms of effectiveness have not as yet been clarified in detail. Therefore I planned to clarify them using experimental animals and procedures. Materials and methods : Four kinds of tumor cell suspensions (3 x 10^4/0.03 ml, 5 x 10^4/0.05 ml, 1 x 10^5/0.1 ml, 1 x 10^11/0.1 ml) were prepared for inoculation to search for optimal tumor adaptation, which 1 defined as obtaining tumors sized about 10～20 mm in diameter at 14 days after inoculation. I examined the Imipenem cilastatin sodium (IPM/CS) suspensions of two volumes of ioxalic acid (10 ml and 20 ml) and the embolization effect was evaluated by microscopic examination of tumor tissue excised immediately after the transcatheter arterial microcmbolization. Results : As a result, it was determined that the cell suspension of 5 x 10^4/0.05 ml afforded the most stable tumor growth in rabbit auricles. A IPM/CS-ioxalic acid suspension of a compounding ratio of 0.5 g/10 ml offers the most suitable microembolizalion effect in rabbit VX 2 tumors certified by microscopic examinations. Conclusions : This experimental animal model and the embolization material of the IPM/CS-ioxalic acid suspension are promising for use in further study and clarification of the mechanism of super-selective transcatheter arterial chcmo-microembolization. (Accepted on May 13, 1999) Kawasaki Igakkaishi 25 (1) : 47―54, 1999
