basic studies on selective intra-arterial injection of Cisplatin (CDDP) – comparativce studies of tissue concentrations of platinum in tumors and other organs – *
Comparative pharmacokinetic studies of tissue concentrations and plasma concentrations following selective intra-arterial and intravenous injection of CDDP in mature female rabbits with VX 2 rabbit carcinoma implanted in the lower leg were carried out. Twenty eight selective intra-artcral injections of 0.83 or 1.67 mg/kg CDDP to the rabbits were made through the right femoral artery at the branching area of the right saphenous artery and 28 intravenous injections of 0.83 or 1.67 mg/kg CDDP were made through the left auricular vein. Each injection was administered for 15 or 30 minutes by a micro-infusion pump. Pharmacokinetic studies were carried out at 0, 5, 10, 15, 30 and 60 minutes after termination of the CDDP injection, and revealed the same characteristics between intra-arterial injections and intravenous injections. Measurement of platinum concentrations in the tumor, muscles around the tumor, the liver, kidney, lung, uterus and tongue were carried out at 0 and 60 minutes after termination of CDDP injection. Platinum concentrations were the highest in the kidney. Those in the tongue, lung and uterus after intravenous injection, were significantly high. The area under the platinum-time curve (AUC) of tissue concentrations in the lung with intravenous injection, was about twice as high as that with selective intra-arterial injection. The AUC in the tumors with selective intra-arterial injection was about 1.4 times higher than that with intravenous injection. In the group receiving selective intra-arterial injection of CDDP 0.83 mg/kg for 15 minutes, the platinum concentration in the tumor was the highest and in the renal tissue was the lowest. (Accepted on October 24, 1998) Kawasaki Igakkaishi 24(4 ): 211-219, 1998
