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Online edition:ISSN 2434-3404

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Expression of parathyroid hormone-related protein and its receptor in human myeloma cell lines *

To analyze the mechanisms involved in hypercalcemia in multiple myeloma, the reverse transcriptase-polymerase chain reaction for parathyroid hormone-related protein (PTHrP) and its receptor (PTH/PTHrP-R) was perfomed using seven human myeloma cell lines established at Kawasaki Medical School. The expression of PTHrP was found in six out of seven lines and PTH/PTHrP-R was detected in three of these lines. In addition, although the lines which strongly expressed PTHrP showed less expression of PTH/PTHrP-R, low or negative lines for PTHrP expression exhibited controversial PTH/PTHrP-R expression. These results may contribute to the examination of the cell biological interactions between cytokines which possess an osteoclast-activating effect and PTHrP. (Accepted on January 27, 1998)

Author
Otsuki T, et al
Volume
23
Issue
4
Pages
227-234
DOI
10.11482/KMJ23(4)227-234.1997.pdf

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