Comparison of Myocardial 123I-labeled fatty acid, 15-(p-iodophenyl)-3R,S-methylpentadecanoic acid (BMIPP) Uptake and Left Ventricular Function in Hypertrophic Cardiomyopathy
A comparative study of myocardial 123I-BMIPP uptake and left ventricular (LV) function in 17 cases with hypertrophic cardiomyopathy (HCM) was performed. Scintigrams using 123I-BMIPP were obtained at 20 min and 2 hr after intravenous injection. The uptake ratio of the heart to upper mediastinum (H/M) in anterior planar images and the defect score (DS) in SPECT images were assessed. LV function was assessed by ECG-gated RI angiography using 99mTc-RBC. LV ejection fractions (EF) in a resting condition (EFRest) and during exercise stress (EFex), and AEF ( = EFEx―EFRest) as an index of LV functional reserve were also calculated. There were significant correlations between the DS and LV functional parameters, but there were no correlations between the 123I-BMIPP uptake ratio and LV function. In conclusion, SPECT using 123I-BMIPP proved to be useful in assessment of LV function and functional reserve in HCM.
