Multiorgan Involvement of Light Chain Deposition Disease ― Report of an Autopsy Case ―
An autopsy case of light chain deposition disease is reported here. A 60-year-old female with plasmacytosis of the bone marrow was disclosed to have amorphous eosinophilic deposits in the kidneys and lungs. Glomerular deposits in kidneys were reminiscent of diabetic nodular glomerulosclerosis. Immunohistochemistry disclosed that they were composed of κ-light chain. Systemic deposition of κ-light chain may occur and should be kept in mind whenever eosinophilic amorphous substance is found in the background of plasma cell dyscrasias.
