Suppression of Protein A Production Decreases the Resistance of Staphylococcus aureus to the Bactericidal Effect of H2O2
Using several strains of Staphylococcus aureus, the resistance to the bactericidal effect of H202 was investigated. The protein A production in the bacteria of Cowan I, Smith and 209P strains which are capable to produce protein A on BHIA could be effectively suppressed by the cultivation on MSA. The viability of the bacteria which suppressed the protein A production was decreased by the incubation with H202. The protein A deficient Wood 46 strain did not show any difference in survival rate between those grown on BHIA and MSA. These results suggested that protein A was related to the resistance to the bactericidal effect of H202.
