SELECTIVE INHIBITION OF ANDROGEN ACTION BY FERULIC ACID IN THE RAT PROSTATE
Slight but significant reduction occurred in the binding of testosterone to cytosol protein of ventral prostate and seminal vesicles by ferulic acid in vitro, but not in the binding of 5α-dihydrotestosterone. Incorporation of amino acids into either cytoplasmic particles or cytoplasmic soluble proteins was not inhibited by ferulic acid administered at a daily dose of 25 mg/kg for 3 days, but the uptake into acid-soluble cytosol fraction was significantly suppressed exclusively in the ventral prostate. Ferulic acid reduces the intracellular pool size of free amino acids in the ventral prostate and subsequently affects the diverse cellular functions, while the transport systems of neutral amino acids and the receptor mechanism of androgen action remain intact.
