An investigation of the radiosensitization effect of indomethacin on tumor cells *
It is well known that indomethacin, which is nonsteroidal anti-inflammatory drug, has an anti-tumor effect and a radiosensitization effect. In this study, the radiosensitization effect of indomethacin was examined using a hamster into which Green's melanoma had been transplanted. The radiosensitization effect on normal tissue of indomethacin was evaluated by hamster's skin reaction. It's skin reaction score was higher for the experimental group than the control group,although the difference between the two groups was shown statistically insignificant. The radiosensitization effect of indomethacin on the tumor was evaluated by the tumor volume ratio,which was calculated based on the tumor volume immediately after irradiation. A statistically significant difference was indicated between the tumor volume ratio of the experimental group and that of the control group from 11 days after the irradiation (11days after: p<0.05; 25 days after: p<0.01) These results showed a clear radiosensitization effect of indomethacin on tumor cells, while the normal cells were unaffected. (Accepted on January 6, 2010)
