RADIOSENSITIZING EFFECT OF MISONIDAZOLE ON MAMMARY CARCINOMA OF C3H MICE
Local tumor control rates and histopathological changes of spontaneous mammary carcinoma of C3H mice were investigated to assess the radiosensitizing effect of misonidazole (2-nitroimidazole). The dose of radiation to control a half of tumors was reduced to about 1/2 after i. p. administration of the drug. Histopathological study also elucidated a marked radiosensitizing effect of the drug to hypoxic cells in the tumor.
