USE OF ACEBUTOLOL FOR STABILIZATION OF CIRCULATORY DYNAMICS FOLLOWING CRUSH INTUBATION
Effect of premedication with acebutolol (0.5±0.1 mg/kg) on the circulatory dynamics was studied compared with that with propranolol (0.05±0.01 mg/kg) and with no drug in patients in whom crush endotracheal intubation was carried out under light thiamylal anesthesia. The premedication with acebutolol avoided definitely the increase in heart rate following laryngoscopy and endotracheal intubation but not with propranolol. However either acebutolol or propranolol could not avoid the increase in blood pressure as much as that without beta blocker premedication. ED50 of acebutolol which could suppress the increase in heart rate was estimated 0.3 mg/kg under such condition. No adverse effect of acebutolol was observed in this series. The above data suggest that subclinical dose of acebutolol can be used to reduce cardiac load and to prevent provocation of latent cardiac failure following endotracheal intubation.