AMINO ACIDS OF SERUM AND URINE IN FAMILIAL AMYLOIDOTIC POLYNEUROPATHY: STUDY ON THE NON-AFFECTED SUBJECTS IN THE FAMILIES
An anylysis of amino acids of serum and urine was performed in four non-affected subjects and four patients in the families with amyloidotic polyneuropathy. 1. The concentration of all free amino acids in both serum and urine of the non-affected subjects was similar to those of the patients (statistically not significant). 2. There were no unusual peaks in any analysis of urine or serum in both groups. 3. The amount of lysine in serum of the non-affected subjects was higher than the patients (P < 0.01). The amount of glycine in serum of the non-affected subjects was less than the patients (P < 0.05). 4. The marked decrease of total amount of amino acids in the urine was found only in one case with 5 years duration of the illness. This case also showed absent of methionine, leucine, and isoleucine in the urine.
