Cellulitis caused by Streptococcus pyogenes at the Bacille Calmette-Guérin vaccination site: A case report
Recently, the number of reports on skin manifestations, including tuberculids, developing as adverse reactions to the Bacille Calmette-Guérin (BCG) vaccine has increased in Japan. We encountered a case in which an infant developed cellulitis at the vaccination site. The patient was a girl who received the BCG vaccine 5 months after birth. Two months after vaccination, she developed a fever of 39ºC, and redness and swelling spread to the entire left upper arm. After being treated with oral cefditoren pivoxil, she was referred to our hospital and received treatment with intravenous sulbactam/ampicillin. Streptococcus pyogenes was detected in a culture of the vaccination scars, and the reaction was very likely caused by pathogenic bacteria. There has been no previous report on a patient developing cellulitis following BCG vaccination caused by S. pyogenes at the vaccination site. Here, we describe such a case with a literature review.
