Hutchinson’s sign in trigeminal nerve zoster: an analysis of 35 cases *
To identify the characteristic cutaneous manifestations associated with ocular complications, a total of 35 patients with herpes zoster developed in the area innervated by the first and second branches of trigeminal nerve were evaluated. Patients diagnosed and treated at the Department of Dermatology, Kawasaki Medical School Hospital from 1998 through 2007 were included in this retrospective study. Although Hutchinson's sign has been demonstrated to be a significant sign of the presence of ocular complications, there were no ocular complications in cases with Hutchinson's sign due to maxillary nerve（the second branch of the trigeminal nerve）zoster. Several cases with ocular complications without Hutchinson's sign were identified and these cases showed both vesicles and edema on the eyelid. Cases with vesicles and edema on the eyelid were also revealed to have a higher rate（66.7％）of complicating severe ocular diseases including keratitis in addition to conjunctivitis. These results indicate that not only Hutchinson's sign but also eyelid eruptions could be a predictor of ocular complications in herpes zoster of the first branch of the trigeminal nerve. (Accepted on October ７，2008)
