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Online edition:ISSN 2434-3404

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A case of ‘Giant’ aneurysmal fibrous histiocytome *

  Aneurismal fibrous histiocytoma(AFH)is an unusual variant of fibrous histiocytoma with large blood-filled cystic spaces that are devoid of endothelial lining. We report the case of a 32-year-old man who presented with an asymptomatic cutaneous tumor on the extensor surface of the right thigh that had grown rapidly in size over a four-month period. Examination revealed a dusky red, round tumor with a smooth, slightly keratotic surface, measuring 8×8cm. Color Doppler examination revealed blood flows in and out of a large hypoechoic cavity. Histopathological examination disclosed a large blood-filled cystic space without endothelial lining and spindle/histiocytic cell lesions containing foamy macrophages with large numbers of dilated blood vessels. On immunohistochemistry, the tumor cells were negative for CD34 and positive for factor XⅢa and vimentin. The histological features of AFH and the importance of its differential diagnosis from other malignant lesions are discussed. (Accepted on April 10,2007)

Author
Kasaoka S, et al.
Volume
33
Issue
4
Pages
307-311
DOI
10.11482/2007/KMJ33(4)307-311,2007.pdf

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