Cord blood transplantation for patients with advanced hematological malignancy *
We report the results of cord blood transplantation in four adult patients with advanced hematological malignancy. The first patient did not achieve engraftment, and the second patient died of acute GVHD after engraftment, but the remaining two patients are alive in complete remission more than 17 and 14 months after transplantation, respectively. This study suggests that engraftment is related to the number of CD34-positive cells infused and the intensity of total body irradiation as a conditioning regimen, and that it is important for patients to receive intense immunosuppressive therapy during a period of acute GVHD. (Accepted on January 16, 2004)
