Online edition：ISSN 2758-089X
The occurrence of asbestos-related diseases in workers, family members of workers, and residents of neighborhoods surrounding asbestos-treated factories had been one of the most important public issues medically, socially, and politically in Japan in 2005. Although the mass-media bring have not, in dealing with the problem of asbestos-induced diseases, focused on medical and preventive issues, the medical science must elucidate the cellular and molecular effects of asbestos on various human cells and organs to establish the best methods for prevention of asbestos-related health disturbances such as asbestosis, lung cancers and malignant mesotheliomas.
The International Agency for Research on Cancer（IARC）categorizes asbestos（e.g. chrysotile, crocidolite, and amosite）and crystalline silica as group I carcinogens. According to the IARC classification, asbestos affects alveolar epithelial and mesothelial cells. There have been many studies concerning asbestos-induced apoptosis in these cells.
In this review, we summarized the basis of asbestos and asbestos-related diseases. In addition, we briefly summarized studies exploring the mechanisms by which asbestos causes apoptosis.
- 三浦 由恵，他