Online edition:ISSN 2758-089X

A Comparison of Scintigraphy with Tumor-seeking Radiopharmaceuticals to Detect an Experimental Bone Tumors in the Rabbits

A comparative study on the accumulation of 99mTc- phosphorous compound, 99mTc-hexakis-2-methoxy isobutyl-isonitrile (MIBI), and 99mTc-tetrofosmin (TF) in the experimental bone tumors using the VX-2 cell was performed. In the group of the femoral metastatic bone tumor, 99mTc-MIBI showed no accumulation in the femur at 12 days after the transplantation despite the presence of a bone marrow tumor. In the group of the iliac metastatic bone tumor, a bone scintigraphy showed decreased accumulation in the ileum at 16 days, but hot lesions were observed in same sites at 18 days after the transplantation on 99mTc-MIBI and 99mTc-TF scintigrams. The tumor to soft tissue accumulation ratio was higher for 99mTc-MIBI (3.03 + 1 03) than for 99mTc-TF (2.55+0.80) (P<0.05). This study showed that 99mTc-MIBI is less satisfactory for the early diagnosis of tumors than bone scintigraphy, and a combined study with both 99mTc-phosphorous compounds and 99mTc-MIBI is useful for the evaluation and diagnosis of lesions.

OTSUKA N, et al