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Online edition:ISSN 2758-089X

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Review of Regulation for the Fas-mediated Apoptotic Pathway in Silicosis Patients

The past several years, we have been investigating immunological aspects of silicosis focusing on Fas-mediated apoptosis. We found elevated serum level of soluble Fas (sFas) molecule, higher gene expression of sFas and decoy receptor 3 (DcR3) genes in peripheral blood mononuclear cells (PBMC) than healthy volunteers, and various alternatively spliced Fas transcripts in PBMC. The factor analysis using these results indicated that there were a small number of patients who developed immunological diseases without presenting with respiratory disorders. In addition, we discuss the mechanism involved in the development of autoimmune disorders found in silicosis patients.

著者名
OTSUKI T, et al
29
1-2
33-43
DOI
10.11482/KMJ-E29(1/2)033

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