Use of Clonazepam in Mania
A combination clonazepam and psychotropic drugs was used to treat 21 manic patients. The symptoms of two patients who received a high daily dose of clonazepam (8-12 mg) dramatically improved. However, the symptoms of the other 19 patients who received a low daily dose of clonazepam (0.5-3 mg) did not improve. High daily doses of clonazepam have a rapid onset of action and show severe side effects. Therefore, we advocate clonazepam should at this time be considered only as a treatment alternative in patients nonresponsive to conventional therapy and should be used in a high daily dose in combination with other psychotropic drugs.