Prognostic Factors of the Outcome of Cervical Intraepithelial Neoplasia in Association with Human Papillomavirus in Patients with Long-term Follow-up
Objective: To retrospectively analyze the risk factors for the persistence and progression of cervical intraepithelial neoplasia (CIN) in patients with long-term follow-up. Patients and Methods: Charts were reviewed to select patients with a diagnosis of CIN, who had been followed up with or without surgical treatments, that is, vaporization or conization. The baseline status of human papilloma virus (HPV) infection was unknown. HPV has been tested along with cytological evaluation for the patient at every visit since then until April 1998. Patients who could be followed up for more than 12 months were analyzed to determine the risk factors for persistent or progressive CIN. Results: An analysis of 314 visits by 66 patients was made. The madian overall follow-up duration of the patients was 45 months (range 16-192). The cytological outcome was normalized in significantly more patients with a lower HPV positive rate (p=0.0276), and it was significantly better in those patients who had undergone vaporization or conization (p=0.0286), particularly in those patients with higher grade CIN. Conclusion: Destructive surgical treatments and an HPV positive rate could be prognostic factors for the cytological outcome of CIN.