Role of paraffin-section immunohistochemistry in the diagnosis of malignant lymphoma
Immunohistochemistry plays an integral role in the diagnosis of malignant lymphoma. The recent development of antibodies against fixative-resistant epitopes, the improvement of antigen retrieval techniques, and the introduction of highly sensitive detection systems have expanded the possibility of immunophenotyping of malignant lymphoma in routinely processed paraffin sections. This review provides precise information regarding antibodies useful in paraffin-section immunohistochemistry, as well as strategies for the immunohistochemical diagnosis of malignant lymphoma based on up-to-date classification.
