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An Insight into Heterozygous β-Thalassemia, Myanmar

There are many differential diagnoses of hypochromic microcytic anemia. In Myanmar congenital and acquired hemolytic anemias and iron deficiency anemia are top listed as common causes. The frequency of β-thalassemia is about 4.3% in Myanmar. Since most of heterozygous β-thalassemias (β-thalassemia traits) are asymptomatic and, more importantly, laboratory facility is very limited, the establishment of diagnosis of it is difficult. Here we report 12 cases of Myanmar voluntary subjects with β-thalassemia trait (parents of thalassemia major patients) and the findings of high performance liquid chromatography and isoelectric focusing of their hemolysates. From this small scaled study, we observe that β-thalassemia traits of high Hb A2 type is more common than that of high Hb F type in Myanmar. Features of δβ-thalassemia heterozygote are not observed.

著者名
Harano T, et al
26
3
127-131
DOI
10.11482/KMJ26(3)127-131.2000.pdf

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