Paradoxical Growth Enhancement of Myeloma Cells Induced by Interferon-α
To evaluate and generalize the effects of IFN-α on myeloma cells, their growth features were studied using 14 myeloma cell lines established at Kawasaki Medical School. Although 5 out of 14 lines showed significant growth inhibition, two lines revealed growth enhancement. Furthermore, this growth enhancement disappeared when JAK/STAT signaling was inhibited using AG490. Further investigations of which molecules are involved in this growth enhancement and what cellular characteristics affect the growth response in myeloma cells against IFN-α are necessary.