Scar Sarcoidosis can be an Expression of the Isomorphic Response of Koebner against the Scar
Two cases of scar sarcoidosis are presented with a proposed new insight into its pathomechanism. This type of sarcoidosis is well known to reflect the clinical and laboratory activities of sarcoidosis. The clinical observation of scar sarcoidosis was reminiscent of expression of the isomorphic response of Koebner in sarcoidosis. The generally accepted findings of scars are the presence of inflammatory cells and substances including fibroblasts, histiocytes, lymphocytes, mast cells and their released cytokines, lymphokines, enzymes, etc. Some locally activated unknown factors such as interferon-α may activate and attract sarcoidosis into scar tissues. Certain common substances in scars and also in the Kveim antigen should be explored in sarcoidosis.
