h_kaishi
Online edition:ISSN 2758-089X

t_toukou

Bifunctional Action of Imipramine on Protein Kinase C from Rabbit Platelets in Vitro

Protein kinase C from rabbit platelets in vitro is inhibited by 1.0 mM imipramine, which is a tricyclic antidepressant. However, 0.2 mM imipramine activated protein kinase C activity from rabbit platelets. Imipramine had a bifunctional action to protein kinase C from platelets in vitro. It is reported that activation of protein kinase C is associated with inhibition of monoamine reuptake in platelets. It is supposed that inhibitory effect of 5-HT uptake of imipramine may, at least in part, be associated with its stimulatory effect on protein kinase C.

著者名
Morishita S, et al
22
1
23-26
DOI
10.11482/KMJ-E22(1)23-26.1996.pdf

b_download