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Online edition:ISSN 2758-089X

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The Direct Effect of Neuroleptics on C-kinase and M-kinase in Rat Brain

Phospholipid-sensitive Ca2+-dependent protein kinase (C-kinase) and its catalytic fragment (M-kinase) were extracted from the rat cerebral cortex. Chlorpromazine and mosapramine inhibited the activity of C-kinase and M-kinase. Haloperidol inhibited the activity of M-kinase. Sulpiride have no effect on C-kinase and M-kinase. These neuroleptics have different effects on clinical psychiatric symptoms. It is possible that the differential effect of neuroleptics may be related to the second messenger level.

著者名
Morishita S.
20
1.2
53-56
DOI
10.11482/KMJ20(1.2)53-56.1994

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