The Direct Effect of Neuroleptics on C-kinase and M-kinase in Rat Brain
Phospholipid-sensitive Ca2+-dependent protein kinase (C-kinase) and its catalytic fragment (M-kinase) were extracted from the rat cerebral cortex. Chlorpromazine and mosapramine inhibited the activity of C-kinase and M-kinase. Haloperidol inhibited the activity of M-kinase. Sulpiride have no effect on C-kinase and M-kinase. These neuroleptics have different effects on clinical psychiatric symptoms. It is possible that the differential effect of neuroleptics may be related to the second messenger level.