Online edition:ISSN 2758-089X

Serum Levels of 7S Collagen in HCV-Ab Positive Chronic Liver Diseases

Serum 7S collagen was measured in 100 patients with Hepatitis C virus (HCV)-Ab positive chronic liver disease using RIA kit (7S-RIA : Japan DPC Corporation). The serum levels of 7S collagen were significantly higher in all types of liver diseases than those in 20 healthy controls (3.9±0.4 ng/ml). The 7S collagen level was 8.4±3.6 ng/ml (n = 30) in chronic hepatitis (CH), 14.4±8.1 ng/ml (n = 30) in liver cirrhosis (LC), 14.5 ±8.6 ng/ml (n=40) in hepatocellular carcinoma (HCC). In chronic hepatitis, chronic active hepatitis had a mean 7S collagen value of 9.8±3.8 ng/ml (n=19), while that of chronic inactive hepatitis was 6.1±1.8 ng/ml (n=11). In decompensated liver cirrhosis, the 7S collagen value was 17.6±9.2 ng/ml (n=17), whereas that of compensated LC was 10.2±3.1 ng/ml (n=13). In HCC, 7S collagen was examined according to the size of the tumor. In HCC with a diameter of less than 3 cm, the value was 11.0±4.2 ng/ml (n = 5). In 3 to 5 cm lesions, it was 12.5±5.8 ng/ml (n=16) and those more than 5 cm in diameter, it was 17.1 ±10.8 ng/ml (n=19). Although there were no significant differences according to size, there was a tendency for the level of 7S collagen to increase with the size of the tumor. The HCV-Ab titer and 7S collagen level showed no significant correlation. Measurement of serum 7S collagen may be useful for the evaluation of the degree of progression of LC and HCC.

Takatori K, et al