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Online edition:ISSN 2758-089X

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Monoamine Interaction ―Effects of Long-Term Treatments with L-tryptophan and Setiptiline Maleate on Rat Brain a2- and β-adrenergic Receptor―

The role of serotonin precursor L-tryptophan and the new tetracyclic antidepressant Setiptiline Maleate in the regulation of β-and α2-adrenergic receptor was examined by Radio Receptor Assay method. Treatment with either L-tryptophan (300 mg/kg, twice, daily) or Setiptiline Maleate (3 mg/kg, twice, daily) for 14 days caused a significant decrease in the number of β-adrenergic receptors (Bmax) measured 12 hours after the last dose. Treatment with co-administration of both L-tryptophan and Setiptiline caused no significant difference from that of either L-tryptophan or Setiptiline alone. Treatment with Setiptiline caused a significant decrease in the number of α2-adrenergic receptor (Bmax), but treatment with L-tryptophan caused no change in it. Treatment with co-administration of both Setiptiline and L-tryptophan potentiated the decrease in the number of α2-adrenergic receptors compared with single administration of Setiptiline alone.

著者名
Katsuda Y.
17
1.2.3.4
37-45
DOI
10.11482/KMJ-E17(1.2.3.4)37-45.1991

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