Biodegradation of Isoflurane in Dogs
The uptake, elimination and biodegradation of isoflurane were studied in 12 mongrel dogs. The amount of isoflurane taken up by the body during three hours of either 1.5% or 0.5% isoflurane anesthesia was measured and the subsequent elimination of isoflurane in the expired gas was measured for five hours. The excess urinary excretion of fluoride were measured during 72 postanesthetic hours. It was revealed that 94.3% of the isoflurane taken up by the body was exhaled in an unaltered form after isoflurane anesthesia. No excess urinary excretion of fluoride was detected at either of the inspired concentrations of isoflurane for the 72 hour period after isoflurane anesthesia.