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Online edition:ISSN 2758-089X

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The Survey of the Frequency of Single and Triplicated α-Globin Gene Loci and Their Imbalance in Japanese

A survey of an interchromosomally unequal but homologous crossover in human α-globin gene cluster was performed with the DNA of the healthy Japanese adults. Of 200 haplotypes, 4 were found to be unusual α-globin gene clusters ; two were the triplicated[-α2-α2-α1-] generated by leftward crossover and the other two were the single [-α2α1(orα1)] created by rightward crossover. However, these identified haplotypes of single and triplicated a gene were not correspond in each to a reciprocal counterpart, produced by the same crossing over mechanism. Individuals with these unusual α-globin gene haplotypes showed neither clinical nor hematologic abnormalities.

著者名
Shimasaki S, et al
12
2
77-82
DOI
10.11482/KMJ-E12(2)77

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