Changes in the Collagen Binding Property of Human Plasma Fibronectin with Aging
We investigated changes in quality of plasma fibronectin with aging, especially in the interaction of fibronectin with collagen, using an enzyme-linked immunosorbent assay. When fibronectin isolated from the plasma of young people was compared with that from old people, the latter was found to bind poorly to gelatin, Type I and Type III collagens. No differences in molecular weight were detected between the two types of fibronectin by SDS-polyacrylamide gel electrophoresis.
