The Effect of Tape Stripping Treatment of Guinea Pig Skin on the Induction of Delayed Hypersensitivity
The induction of CS to DNCB was impaired if DNP-EC was injected subcutaneously through the skin that was stripped with cellophane tape immediately before the antigen application. The suppressive effect of tape stripping on DNP-EC induced CS was abrogated when normal PM was mixed and injected subcutaneously with DNP-EC into stripped skin. By contrast, tape stripping treatment before BCG or OVA in FIA administration had not influence on development of these delayed hypersensitivity. Significance of these findings is discussed.