Effect of Ascorbic Acid on Bronchoconstriction Induced by Methacholine Inhalation Challenge in Healthy Subjects
We investigated the effect of ascorbic acid (1.0 g orally) on bronchoconstriction induced by methacholine inhalation challenge in five healthy subjects. We also measured the serum concentration of ascorbic acid on the control day and on the ascorbic acid day. The serum ascorbic acid levels in all subjects increased on the ascorbic acid day. The protective effect of ascorbic acid against bronchoconstriction was demonstrated in three subjects. The results suggest an anti-bronchoconstrictive action of high dose ascorbic acid in some cases.