Prostaglandin E Production in Bone Lesion of Transplanted VX-2 Tumor in Rabbits
The correlation between prostaglandin E (PGE) and advance of tumor metastasis was investigated in normal and VX-2 bearing rabbits. PGE in plasma of normal rabbits was 486.2± 185.7 pg/ml (n=86). In rabbits with VX-2 dispersed into heart cavity, the circulating PGE levels increased when tumor cells lodged and proliferated in the lymphnode, lung, liver and bone marrow. However, the plasma levels of PGE in the rabbits with bone involvement were significantly higher than those without bone involvement. This data indicates that PGE produced at the bone lesion may mediate the osteoclastic bone resorption and destroy bone. In vitro studies revealed that PGE level increased in the culture medium of VX-2 tumor cells, while an appreciable increase was not noted in HeLa S3.
