Studies on Lipid of Red Cell Membrane in Patients with Iron Deficiency Anemia by the Use of Iatroscan
Studies on red cell membrane lipid composition in patient with iron deficiency anemia (IDA) disclosed the possibility of abnormal metabolism of cellular membrane. Inversion of the SM/PC ratio (SM, sphingomyelin and PC, phosphatidyl choline, are the lipids of the outer lamella of erythrocyte membrane) might be responsible for the poikilocytosis seen in this anemia. In IDA patients, phosphatidyl ethanolamine (PE) and phosphatidyl serine (PS), which are the lipids of inner lamella of the membrane decreased, but they returned to the normal range with increase in reticulocytes which were produced in accordance with the beneficial effect of the iron therapy.
