Influence of Ethanol Pretreatment on Serum Complement Levels in Rats Treated with Carbon Tetrachloride
Pretreating male Wistar rats with a single oral dose (6ml/kg) of ethanol clearly potentiated the CCl4-induced hepatotoxicity (0.2 ml/kg ip), as shown by the elevated SGOT and SGPT levels, or histopathological observation of the liver sections. Serum hemolytic complement (CH50) and C3 levels were slightly reduced by the administration of CC14, but significantly reduced when rats were treated with ethanol 18 hours prior to CC14 administration.
