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Online edition:ISSN 2758-089X

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EFFECT OF MERCURIC CHLORIDE ON THE THYROID FUNCTION IN RATS

Mercuric chloride (HgCl2) intraperitoneally administered to male Sprague-Dawley rats was associated with decrease in 24-hr thyroid 131I-Uptake, thyroid weight, serum protein bound131I, conversion ratio and thyroid-to-serum131I ratio. Chromatographic analyses of pronase-thyroid hydrolysates of the HgCl2-treated rats revealed a depression in synthesis of thyroid hormones. The thyroid function in male Sprague-Dawley rats seemed to be more susceptible to HgCl2 than in male Wistar rats, while no significant difference was observed between both sexes of Wistar rats.

著者名
Mochizuki Y, et al
4
2
113-119
DOI
10.11482/KMJ-E4(2)113

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