DEVELOPMENT OF VIRAL PARTICLES FROM PURIFIED SV 40 DNA IN TRANSFORMING HUMAN CELLS
In vitro cell transformation of human embryonic cells could be induced by DNA extracted from virions of SV 40 purified by density gradient centrifugation. The results shows clearly that cell transformation is induced by incorporation of a part of viral DNA into the genome. On the other hand it has been revealed that viral DNA of SV 40 develop to viral particles in the nucleus of human transforming cells.
